China Education Equipment Procurement Network News: Scientists at the Massachusetts Institute of Technology are developing a new drug that can fight viruses as effectively as penicillin can destroy bacteria. The design principle of this broad-spectrum antiviral drug is to cause cells infected by the virus to commit suicide, thereby preventing infection, while not harming healthy cells.
In laboratory experiments using animal and human cells, the new drug is effective against 15 viruses, including cold viruses, HIN1 influenza virus, dengue virus, polio virus, a stomach virus, and several hemorrhagic fever viruses. Todd Ryder, a senior scientist in the Chemistry, Biology and Nanoscale Technology Group at the MIT Lincoln Laboratory who invented the new technology, said: "In theory, it should be effective against all viruses."
China Education Equipment Purchasing Network News: The principle of this drug is to use human cells to defend against natural infections from viral infections. When a virus infects a healthy cell, it will use the cell's system to serve its own purpose, which is replication. In this process, the virus produces multiple long double-stranded ribonucleic acids (RNA)-this is a sign of cell infection.
Finally, once the virus completes the replication, it immediately kills the host, and then continues to act.
To fight infection, proteins in human cells are connected to double-stranded RNA, triggering a series of reactions that prevent the virus from replicating itself. Ryder thought of combining one of these proteins with another to trigger cell suicide. This process is called apoptosis.
The final result is a drug called DRACO. After one end of the DRACO is connected to the double-stranded RNA, the other end of the DRACO is instructed to start the process of apoptosis, thereby killing the cells before the virus has a chance to replicate.
Carla Kirkgard, a professor of microbiology and immunology at Stanford University, said: "For what we are trying to use to fight them, viruses are quite good at forming resistance, but for this drug, it is difficult to think of a simple way to cause resistance. "
In the trial, DRACO completely cured mice infected with HINI influenza virus. The researchers believe that it is possible to use this drug to stop the outbreak of new viruses such as SARS.
Scientists are currently testing DRACO against more viruses in mice. They said they hope to be allowed to test this technology on larger animals, and one day they will be tested on humans. (Xie Yinan / Editor)
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